Curatopes Melanoma: A database of predicted T-cell epitopes from overly expressed proteins in metastatic cutaneous melanoma

About this table: Superior-tolerance epitopes are predicted to show negligible RNA expression (< 10 TPM) in survival-critical tissues. This table lists the best three epitopes (by gPIE score) for each combination of Gene of Origin and HLA allele.

Genes in this table: C11orf71 CSNK2A3 GPR89A GPR89B GTF2H2C MAGEA3 NBPF20 PGAM4 PSMG4 RAMACL RIOX1 SMIM10L1 TIMM23B TRAPPC9 USP41

About this table: Enhanced-tolerance epitopes are predicted to be expressed above 10 TPM in some survival-critical tissues. This table lists the best three epitopes (by gPIE score) for each combination of Gene of Origin and HLA allele.

Genes in this table: ATOX1 COX7A2L ELOC HSBP1 KRTCAP2 MCTS1 MPLKIP MRPS33 NACA NDUFA11 PCLAF PIGF RAN RPL37 RPS19 RPS27L SERF2 SMUG1 TMBIM4 TXNL4A

About this table: This table lists all epitopes that passed the Curatopes filters. It contains both Superior-tolerance and Enhanced-tolerance epitopes

Genes in this table: ATOX1 C11orf71 COX7A2L CSNK2A3 ELOC GPR89A GPR89B GTF2H2C HSBP1 KRTCAP2 MAGEA3 MCTS1 MPLKIP MRPS33 NACA NBPF20 NDUFA11 PCLAF PGAM4 PIGF PSMG4 RAMACL RAN RIOX1 RPL37 RPS19 RPS27L SERF2 SMIM10L1 SMUG1 TIMM23B TMBIM4 TRAPPC9 TXNL4A USP41

About this table: These melanoma-specific epitopes were extracted from the CAPED database which lists epitopes with the confirmed capacity to induce an immune response. Several are the subject of past or ongoing clinical trials on their therapeutic efficacy against metastatic melanoma. While none of them passed the Curatopes filters, they serve as a valuable point of reference for our results.

Genes in this table: CDKN2A CLPP CSNK1A1 CTAG1B DCT FOLH1 GAS7 GPR143 HAUS3 MLANA PMEL PPP1R3B PRAME RAB38 TYR

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